A grant from HHS-NIH11
This NIH opportunity supports pilot projects that generate preliminary data and/or tools to characterize an eligible understudied protein in the context of rare disease.…
Award
Up to $100,000
Deadline
November 16, 2027
394 days
No signup · Source checked 10/18/2026
Decision snapshot
Potential award
Up to $100,000
Official deadline
November 16, 2027
394 days
Eligibility evidence
2 confirmed criteria
5 checks available
Application load
Moderate effort
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Eligible nonprofits are named in the source requirements.
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This is an explainable self-assessment, not a win probability or legal determination. Hard eligibility conflicts are never averaged against softer program-fit signals. Always verify the official notice.
Nationwide availability is inferred from the catalog record; confirm the official notice.
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This NIH opportunity supports pilot projects that generate preliminary data and/or tools to characterize an eligible understudied protein in the context of rare disease. Proposed work should center on basic biochemical or biological characterization, use a protein from the NOFO’s specified list, and fit within the stated $100,000 award ceiling.
NIH intends to jumpstart research on eligible understudied proteins associated with rare diseases. Funding supports preliminary data and/or tool generation through basic biochemical or biological work that further characterizes these proteins in a rare-disease context.
The proposed protein appears on the NOFO’s eligible-protein list and is therefore within the specified group of understudied proteins from druggable families with known rare-disease associations. The project is structured as a pilot that will generate preliminary data, research tools, or both, rather than as a large mature research program. The proposed experiments use basic biochemical and/or biological work to further characterize the selected protein in a clearly identified rare-disease context. The proposed scope and budget fit within the stated $100,000 award ceiling; the funding record states that cost sharing is not required. The applicant is among the listed eligible domestic entities, such as a public or private institution of higher education, nonprofit, small business, other for-profit organization, tribal entity, or eligible government body.
The packet does not provide formal review criteria. Based on the stated program purpose, likely priorities include confirmation that the target is on the eligible-protein list, a clear rare-disease context, a focused biochemical or biological plan, and defined preliminary data or tools that further characterization of the protein. These priorities are inferred and should be checked against the full NIH announcement.
The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.
Decision economics
Use the source facts below to judge whether the likely return justifies the application effort.
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National
Working plan
The generated milestones are planning aids. Only the official notice establishes required dates.
Requirements captured
Official deadline
November 16, 2027
Moderate effort based on requirements currently captured.
Confirm eligibility, registrations, partners, and internal approval.
Finalize project design, outcomes, and supporting evidence.
Draft the narrative and detailed budget.
Complete compliance review and collect attachments.
Submit early and preserve the confirmation receipt.
The official record was successfully checked. Verification does not mean every eligibility or application field has been extracted. Read the methodology →
Updated eligibility, eligibility details.
Updated eligibility, eligibility details.
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Updated eligibility, eligibility details.
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Updated eligibility, eligibility details.
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HHS-OPHS
Related by Health and Human Services.
HHS-OPHS
Related by Health and Human Services.
HHS-HRSA
Related by Health and Human Services.
HHS-NIH11
Related by Health and Human Services.
HHS-NIH11
Related by Health and Human Services.
HHS-NIH11
Related by Health and Human Services.
Yes, based on the latest source record. The deadline is November 16, 2027, with 394 days remaining. Because funders can amend or extend notices, confirm the date and submission instructions on the official application page. The source was last checked 10/18/2026.
Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) Grant lists Up to $100,000 per award. The expected number of awards has not been captured, so the award range alone should not be treated as an estimate of competitiveness.
Special district governments; Native American tribal governments (Federally recognized); Small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); City or township governments; Public and State controlled institutions of higher education;… Applicants should still complete the eligibility quiz and verify every condition in the official notice; a general fit does not override exclusions or registration requirements.
No cost-share requirement is indicated in the captured source facts. Applicants should still verify the official budget instructions in case an amendment, program track, or specific cost category carries additional conditions.
Moderate effort is expected. The captured requirements include other requirements, submission system, attachments, contact. Start by confirming eligibility and registrations, then work backward from November 16, 2027 using the preparation plan above.
