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A grant from HHS-NIH11

Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) Grant

This NIMH R01 opportunity is a strong conceptual fit for a statistically powered, definitive effectiveness trial of a post-acute therapeutic or service-delivery intervention for a mental health condition affecting…

Official application

Award

Not specified

Deadline

January 7, 2028

446 days

Apply at official source Check your eligibility

No signup · Source checked 10/17/2026

Decision snapshot

Potential award

Not specified

Official deadline

January 7, 2028

446 days

Eligibility evidence

2 confirmed criteria

5 checks available

Application load

Moderate effort

01

Start here

Confirm eligibility

Check your fit in about 60 seconds.

Eligibility requirementsQuestion 1 of 5
About 60 seconds totalConfirmed criterion

Does your organization have the required nonprofit status?

What does this mean?

Eligible nonprofits are named in the source requirements.

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Does your organization have the required nonprofit status?
Select an answer to continue

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This is an explainable self-assessment, not a win probability or legal determination. Hard eligibility conflicts are never averaged against softer program-fit signals. Always verify the official notice.

Optional Review source criteria and citations

Nonprofit status

Eligible nonprofits are named in the source requirements.

Review source ↗
confirmed

Geography

Nationwide availability is inferred from the catalog record; confirm the official notice.

Review source ↗
inferred

Organization size

No organization-size limit was captured.

Review source ↗
unclear

Program area

Health, Human Services, Youth Development, Research

Review source ↗
inferred

Population served

No specific population was captured.

Review source ↗
unclear

Matching funds

No cost share is indicated.

Review source ↗
confirmed

Registrations

SAM.gov and Grants.gov registration may be required; confirm in the notice.

Review source ↗
inferred

Exclusions

Review the full notice for exclusions and prohibited uses.

Review source ↗
unclear
02

Grant-writer assessment

Understand the opportunity

Start with the practical interpretation. Open the complete source narrative when you need the underlying detail.

Plain-English explanation

Plain-English explanation

This NIMH R01 opportunity is a strong conceptual fit for a statistically powered, definitive effectiveness trial of a post-acute therapeutic or service-delivery intervention for a mental health condition affecting youth, adults, or older adults. Projects should align the intervention’s focus and intensity or burden with the post-acute stage and longer-term aims such as maintaining gains, managing residual symptoms or impairment, preventing relapse, promoting adherence, or appropriate service use. The notice encourages hypotheses about moderators, mediators, and mechanisms. Pilot feasibility, tolerability, acceptability, safety, and preliminary-effectiveness work is directed to a companion R34 rather than this R01. Formal review criteria, budgets, and detailed clinical-trial requirements require confirmation in the full announcement.

Editorial analysis

What the funder is trying to accomplish

NIMH seeks effectiveness trials of therapeutic and service-delivery interventions for post-acute management of mental health conditions affecting youth, adults, and older adults. The trials are intended to establish intervention effectiveness and may test hypotheses about moderators, mediators, and mechanisms of action. Interventions should be matched to the post-acute stage in focus and intensity or burden to promote longer-term outcomes.

Editorial analysis

Strong-fit project signals

The intervention addresses the post-acute phase of a mental health condition rather than initial treatment alone. The study is designed and statistically powered to provide a definitive answer about intervention effectiveness. The intervention is therapeutic or service-delivery focused and concerns a mental health condition affecting youth, adults, or older adults. The intervention is matched to post-acute objectives such as consolidating and maintaining initial-treatment gains, managing residual symptoms or impairment, preventing relapse, promoting adherence, or appropriate service use. The proposal includes scientifically justified hypotheses concerning moderators, mediators, or mechanisms of action alongside the effectiveness trial.

Editorial analysis

What reviewers may prioritize

The evidence packet does not provide formal review criteria or reviewer instructions. Based on the stated program purpose, a proposal should make a coherent case connecting the mental health condition, the post-acute stage, the intervention’s stage-matched focus and burden, the longer-term outcome, and a definitive effectiveness design. If moderators, mediators, or mechanisms are proposed, their hypotheses should be clearly connected to the trial.

Source dossier Read the full official program description
Source-backed synopsis

What this grant funds

NIMH seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions affecting youth, adults, and older adults. This Notice of Funding Opportunity (NOFO) encourages clinical trials to establish the effectiveness and test hypotheses regarding moderators, mediators, and mechanisms of action of post-acute phase therapeutic and services interventions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden for promoting optimal longer-term outcomes. This NOFO is intended to support effectiveness trials testing post-acute phase interventions that are statistically powered to provide a definitive answer regarding the study intervention's effectiveness. Support for pilot effectiveness trials to evaluate the initial feasibility, tolerability, acceptability, safety and preliminary indications of effectiveness of post-acute phase intervention approaches is provided via a companion R34 (Currently TEMP-24814)

Read the complete official description ↗
03

Decision economics

Size the opportunity

Use the source facts below to judge whether the likely return justifies the application effort.

Award range
Not specified
Total program funding
Not specified
Expected awards
Not specified
Geography
National
Cost share
Not indicated
Assistance listing
Not specified

Mission alignment

Compare your program with Health, Human Services, Youth Development.

Geographic fit

National

04

Working plan

Build the application

The generated milestones are planning aids. Only the official notice establishes required dates.

Requirements captured

Other requirements
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Submission system
Grants.gov
Attachments
https://grants.nih.gov/grants/guide/pa-files/PAR-25-207.html, PAR-25-207 Full Announcement Text
Contact
National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

Official deadline

January 7, 2028

Moderate effort based on requirements currently captured.

  1. Confirm eligibility, registrations, partners, and internal approval.

  2. Finalize project design, outcomes, and supporting evidence.

  3. Draft the narrative and detailed budget.

  4. Complete compliance review and collect attachments.

  5. Submit early and preserve the confirmation receipt.

05Past behaviorCompare historical awardsHistorical patterns provide context, but do not predict or guarantee future funding decisions.
No licensed historical awards are currently linked to this opportunity.
06Audit trailVerify the evidenceSee where the facts came from, when they were checked, and what has materially changed.

Source record

What “source verified” means

The official record was successfully checked. Verification does not mean every eligibility or application field has been extracted. Read the methodology →

Verification
verified
Source
grants gov
Last checked
10/17/2026, 12:13:33 PM
Content updated
10/17/2026, 12:13:35 PM
Review
Automated normalization; not yet expert-reviewed
Open official source ↗

Material changes

  1. Updated eligibility, eligibility details.

  2. Updated eligibility, eligibility details.

  3. Updated eligibility, eligibility details.

  4. Updated eligibility, eligibility details.

  5. Updated eligibility, eligibility details.

  6. Updated eligibility, eligibility details.

  7. Updated eligibility, eligibility details.

  8. Updated eligibility, eligibility details.

  9. Updated eligibility, eligibility details.

  10. Updated eligibility, eligibility details.

  11. Updated eligibility, eligibility details.

  12. Updated eligibility, eligibility details.

Verify before applying. Official funder documents control. Derived analysis and preparation dates should not replace the notice.
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Quick answersFrequently asked questionsGet concise answers about Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) Grant.
Is Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) Grant currently open?

Yes, based on the latest source record. The deadline is January 7, 2028, with 446 days remaining. Because funders can amend or extend notices, confirm the date and submission instructions on the official application page. The source was last checked 10/17/2026.

How much funding does Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) Grant provide?

Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) Grant lists Not specified per award. The expected number of awards has not been captured, so the award range alone should not be treated as an estimate of competitiveness.

Who can apply to Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) Grant?

State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public and State controlled institutions of higher education; For profit organizations other than small businesses; Native American tribal governments (Federally recognized);… Applicants should still complete the eligibility quiz and verify every condition in the official notice; a general fit does not override exclusions or registration requirements.

Does Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) Grant require matching funds?

No cost-share requirement is indicated in the captured source facts. Applicants should still verify the official budget instructions in case an amendment, program track, or specific cost category carries additional conditions.

What should I prepare before applying to Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required) Grant?

Moderate effort is expected. The captured requirements include other requirements, submission system, attachments, contact. Start by confirming eligibility and registrations, then work backward from January 7, 2028 using the preparation plan above.