Maevena
Openfederal funding•Federal coverage•Tier 2 intelligence

A grant from HHS-NIH11

Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional) Grant

This is a high-effort NICHD opportunity for innovative, investigator-initiated, multisite clinical trials or observational studies that leverage relevant NICHD clinical research Network infrastructure.…

Official application

Award

Up to $6,250,000

Deadline

November 15, 2027

393 days

Apply at official source Check your eligibility

No signup · Source checked 10/17/2026

Decision snapshot

Potential award

Up to $6,250,000

Official deadline

November 15, 2027

393 days

Eligibility evidence

2 confirmed criteria

5 checks available

Application load

Moderate effort

01

Start here

Confirm eligibility

Check your fit in about 60 seconds.

Eligibility requirementsQuestion 1 of 5
About 60 seconds totalConfirmed criterion

Does your organization have the required nonprofit status?

What does this mean?

Eligible nonprofits are named in the source requirements.

Review supporting source ↗
Does your organization have the required nonprofit status?
Select an answer to continue

No signup · Answers stay in this browser session

This is an explainable self-assessment, not a win probability or legal determination. Hard eligibility conflicts are never averaged against softer program-fit signals. Always verify the official notice.

Optional Review source criteria and citations

Nonprofit status

Eligible nonprofits are named in the source requirements.

Review source ↗
confirmed

Geography

Nationwide availability is inferred from the catalog record; confirm the official notice.

Review source ↗
inferred

Organization size

No organization-size limit was captured.

Review source ↗
unclear

Program area

Health, Income Security and Social Services, Human Services, Youth Development, Community Development, Research

Review source ↗
inferred

Population served

No specific population was captured.

Review source ↗
unclear

Matching funds

No cost share is indicated.

Review source ↗
confirmed

Registrations

SAM.gov and Grants.gov registration may be required; confirm in the notice.

Review source ↗
inferred

Exclusions

Review the full notice for exclusions and prohibited uses.

Review source ↗
unclear
02

Grant-writer assessment

Understand the opportunity

Start with the practical interpretation. Open the complete source narrative when you need the underlying detail.

Plain-English explanation

Plain-English explanation

This is a high-effort NICHD opportunity for innovative, investigator-initiated, multisite clinical trials or observational studies that leverage relevant NICHD clinical research Network infrastructure. It uses a milestone-driven UG3 start-up phase followed by a potential UH3 full-enrollment and implementation phase; transition is contingent on milestone achievement and NICHD administrative consideration. Applications must use a multi-PD/PI structure, include the respective Network DCC or an NICHD-determined equivalent, and provide aims and milestones for both phases.

Editorial analysis

What the funder is trying to accomplish

NICHD intends to leverage its clinical research Network infrastructure for innovative, multisite, investigator-initiated clinical trials and observational studies relevant to infants, children, women, pregnant and lactating women, and persons with disabilities. Projects use a milestone-driven UG3 start-up phase with possible transition to UH3 full enrollment and implementation.

Editorial analysis

Strong-fit project signals

The proposed research directly concerns infants, children, women, pregnant or lactating women, or persons with disabilities. The project is an innovative, investigator-initiated, multisite clinical trial or observational study. The proposed study can meaningfully use relevant NICHD clinical research Network infrastructure. The application can use the required multi-PD/PI structure and be submitted in conjunction with the respective NICHD-supported Network DCC or an equivalent determined acceptable by NICHD. The team can provide specific aims and milestones for both the UG3 start-up phase and the UH3 full-enrollment and implementation phase.

Editorial analysis

What reviewers may prioritize

The packet does not provide formal NIH review criteria. Based on the stated purpose and mechanism, likely considerations include the innovation and population relevance of the hypothesis, substantive use of relevant NICHD Network infrastructure, feasibility of multisite execution, adequacy of the multi-PD/PI and DCC arrangement, and clarity and achievability of the UG3 and UH3 milestones. These are professional inferences, not quoted review criteria.

Source dossier Read the full official program description
Source-backed synopsis

What this grant funds

The purpose of this Notice of Funding Opportunity (NOFO) is to leverage NICHD clinical research Network infrastructure relevant to infants, children, women, pregnant and lactating women, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies. This NOFO will utilize a bi-phasic (UG3/UH3), milestone-driven mechanism consisting of a start-up phase (UG3) and a full enrollment and clinical trial implementation phase (UH3). Applications submitted in response to this NOFO must address specific aims and milestones for both the UG3 and UH3 phases. A UG3 project (phase I) that meets its milestones will be administratively considered by NICHD and prioritized for transition to the UH3 award (phase II). This NOFO provides an opportunity to leverage NICHD clinical research Network infrastructure as a platform for investigator-initiated innovative hypotheses by any investigator in the extramural community. Applications must be submitted as investigator-initiated, multi-Project Director/Principal Investigator (PD/PI) grant applications in conjunction with the respective NICHD-supported Network Data Coordinating Center (DCC), or equivalent as determined by the NICHD.

Read the complete official description ↗
03

Decision economics

Size the opportunity

Use the source facts below to judge whether the likely return justifies the application effort.

Award range
Up to $6,250,000
Total program funding
Not specified
Expected awards
Not specified
Geography
National
Cost share
Not indicated
Assistance listing
Not specified

Mission alignment

Compare your program with Health, Income Security and Social Services, Human Services.

Geographic fit

National

04

Working plan

Build the application

The generated milestones are planning aids. Only the official notice establishes required dates.

Requirements captured

Other requirements
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Submission system
Grants.gov
Attachments
https://grants.nih.gov/grants/guide/pa-files/PAR-25-311.html, PAR-25-311 Full Announcement Text
Contact
National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

Official deadline

November 15, 2027

Moderate effort based on requirements currently captured.

  1. Confirm eligibility, registrations, partners, and internal approval.

  2. Finalize project design, outcomes, and supporting evidence.

  3. Draft the narrative and detailed budget.

  4. Complete compliance review and collect attachments.

  5. Submit early and preserve the confirmation receipt.

05Past behaviorCompare historical awardsHistorical patterns provide context, but do not predict or guarantee future funding decisions.
No licensed historical awards are currently linked to this opportunity.
06Audit trailVerify the evidenceSee where the facts came from, when they were checked, and what has materially changed.

Source record

What “source verified” means

The official record was successfully checked. Verification does not mean every eligibility or application field has been extracted. Read the methodology →

Verification
verified
Source
grants gov
Last checked
10/17/2026, 12:13:27 PM
Content updated
10/17/2026, 12:13:28 PM
Review
Automated normalization; not yet expert-reviewed
Open official source ↗

Material changes

  1. Updated eligibility, eligibility details.

  2. Updated eligibility, eligibility details.

  3. Updated eligibility, eligibility details.

  4. Updated eligibility, eligibility details.

  5. Updated eligibility, eligibility details.

  6. Updated eligibility, eligibility details.

  7. Updated eligibility, eligibility details.

  8. Updated eligibility, eligibility details.

  9. Updated eligibility, eligibility details.

  10. Updated eligibility, eligibility details.

  11. Updated eligibility, eligibility details.

  12. Updated eligibility, eligibility details.

Verify before applying. Official funder documents control. Derived analysis and preparation dates should not replace the notice.
Keep searchingSimilar and alternative grantsExplore verified opportunities related by program area, funder, or funding type.

HHS-OPHS

Making America Healthy Again by Addressing Dementia Disparities

Related by Health and Human Services.

View grant →

HHS-HRSA

Fiscal Year 2027 Regional Nutrition Hubs

Related by Health and Human Services.

View grant →

HHS-OPHS

Promoting Access with a Language Services Assistance Symbol

Related by Health and Human Services.

View grant →

HHS-NIH11

Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)

Related by Health and Human Services.

View grant →

HHS-NIH11

Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (R03 Clinical Trial Optional)

Related by Health and Human Services.

View grant →

HHS-NIH11

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

Related by Health and Income Security and Social Services.

View grant →
Quick answersFrequently asked questionsGet concise answers about Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional) Grant.
Is Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional) Grant currently open?

Yes, based on the latest source record. The deadline is November 15, 2027, with 393 days remaining. Because funders can amend or extend notices, confirm the date and submission instructions on the official application page. The source was last checked 10/17/2026.

How much funding does Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional) Grant provide?

Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional) Grant lists Up to $6,250,000 per award. The expected number of awards has not been captured, so the award range alone should not be treated as an estimate of competitiveness.

Who can apply to Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional) Grant?

Small businesses; Native American tribal governments (Federally recognized); Private institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); County governments; Public housing authorities/Indian housing authorities;… Applicants should still complete the eligibility quiz and verify every condition in the official notice; a general fit does not override exclusions or registration requirements.

Does Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional) Grant require matching funds?

No cost-share requirement is indicated in the captured source facts. Applicants should still verify the official budget instructions in case an amendment, program track, or specific cost category carries additional conditions.

What should I prepare before applying to Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional) Grant?

Moderate effort is expected. The captured requirements include other requirements, submission system, attachments, contact. Start by confirming eligibility and registrations, then work backward from November 15, 2027 using the preparation plan above.